The pursuit of matrix metalloproteinase (MMP) inhibitors began in earnest over three decades ago.Initial clinical trials were disappointing, resulting in a Collections negative view of MMPs as therapeutic targets.As a better understanding of MMP biology and inhibitor pharmacokinetic properties emerged, it became clear that initial MMP inhibitor cli
The pathogenesis of glaucoma is still not fully clarified but a growing body of evidence suggests that neuroinflammation and immune response are part of the sequence of pathological events leading to the Clampmeters optic neuropathy.Indeed, inflammation - involving the activation and proliferation of resident glial cells (astrocytes, Muller cells a
A case of isolated infundibular pulmonary stenosis is reported and literature is reviewed.Infundibular pulmonary stenosis is usually a part of tetralogy of Fallot or is associated with ventricular septal defect.Isolated infundibular pulmonary stenosis is rare.Patients may be asymptomatic in spite of significant stenosis.Dyspnea, chest pain, and pre